Invented by Crist J. Frangakis, William Bauer, Wolfgang Liedtke, Achelios Therapeutics Inc

Migraine is a neurological condition that affects millions of people worldwide. It is characterized by intense headaches, nausea, and sensitivity to light and sound. Migraine attacks can last for hours or even days, and they can significantly impact a person’s quality of life. As a result, there is a growing market for methods and compositions to treat migraine and associated pain.

There are several types of medications that are commonly used to treat migraine. These include over-the-counter pain relievers such as aspirin and ibuprofen, as well as prescription medications such as triptans and ergotamines. However, these medications are not always effective for everyone, and they can have side effects such as nausea, dizziness, and fatigue.

As a result, there is a growing demand for alternative treatments for migraine and associated pain. These treatments can include natural remedies such as herbal supplements, acupuncture, and massage therapy. There are also new technologies being developed, such as neuromodulation devices that use electrical stimulation to alleviate pain.

One promising area of research is the use of cannabinoids to treat migraine. Cannabinoids are compounds found in the cannabis plant, and they have been shown to have pain-relieving properties. Some studies have suggested that cannabinoids may be effective in reducing the frequency and severity of migraine attacks.

Another area of research is the use of botulinum toxin (Botox) injections to treat migraine. Botox is commonly used for cosmetic purposes, but it has also been found to be effective in reducing the frequency of migraine attacks. The injections work by blocking the release of certain chemicals in the brain that are associated with pain.

In addition to treatments for migraine, there is also a growing market for treatments for conditions associated with migraine, such as fibromyalgia and chronic pain. These conditions can be difficult to treat, and there is a need for new and effective therapies.

Overall, the market for methods and compositions to treat migraine and associated pain is growing rapidly. As more research is conducted and new treatments are developed, it is likely that we will see even more options for people who suffer from these conditions. Whether it is through natural remedies, new technologies, or innovative medications, the goal is to provide relief and improve the quality of life for those who suffer from migraine and associated pain.

The Achelios Therapeutics Inc invention works as follows

The present invention relates pharmaceutical compositions containing non-steroidal antiinflammatory drugs (NSAIDs), such as aspirin or diclofenac or ibuprofen or ketoprofen or naproxen or pharmaceutically acceptable salts or solvates thereof and their medical use. These compositions can be formulated to provide an extended release of NSAIDs. “The compositions of this invention can be used, for example, to reduce pain or as a prophylactic measure, or in treating headaches like migraine headaches or their symptoms, or in reducing prophylactic measures or treatments.

Background for Methods and compositions to treat migraine and conditions associated pain


Methods of Treatment.

Inflammatory Pain

Other Types of Pain


Temporomandibular disorders (TMD)

Assessment Of Efficacy

Therapeutic Agents

Combination Therapy/Treatments



Route of Administration


Materials & Methods

Materials and HPLC Analysis”.

Example 1: Formulation Studies

Example 2 – Pharmacokinetic study objectives and endpoint

Example 3 : Phase 1 Study Design

Example 4 : Pharmacokinetic Methodology

Example 5: Pharmacokinetic statistical analysis

Example 6. “Effects of topical administration of ELS-Ketoprofen formulation in pre-clinical trigeminal pain models

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