Category: Therapeutic Antibodies

Invented by George Edwin Katibah, David Kanne, Leonard Sung, Kelsey Gauthier, Laura Hix Glickman, Justin Leong, Sarah M. McWhirter, Thomas W. Dubensky, Jr., Chinook Therapeutics Inc The market for compositions for activating the stimulator interferon gene 13 (STING) dependent signaling is rapidly growing as researchers and pharmaceutical companies recognize the potential of targeting this pathway…

Invented by Manoj K. Sharma, Wendy Benjamin, Sarita Mittal, Ashwin Basarkar, Chakravarthy Nachu Narasimhan, Ramesh S. Kashi, Mohammed Shameem, Soumendu Bhattacharya, Yogita Krishnamachari, Merck Sharp and Dohme LLC The Market for Stable Formulations and Methods for Use of Anti-Programmed Death Receptor 1 Antibodies Introduction: The development of immunotherapy has revolutionized the field of oncology by…

Invented by Jeffrey A. Hubbell, Stephan Kontos, Karen Y. Dane, Ecole Polytechnique Federale de Lausanne EPFL The market for erythrocyte-binding therapeutics is rapidly growing, as more and more pharmaceutical companies are investing in research and development of these innovative drugs. Erythrocyte-binding therapeutics are a type of medication that targets red blood cells, which are responsible…

Invented by Huiquan Han, Qing Chen, Keith Soo-Nyung Kwak, Xiaolan Zhou, Amgen Inc Anti-activin A antibodies are a type of protein that can be used to treat a variety of medical conditions. Activin A is a protein that is involved in a number of important biological processes, including cell growth and differentiation, inflammation, and wound…

Invented by John R. Desjarlais, Seung Y. Chu, Holly M. Horton, Matthew J. Bernett, Xencor Inc IgE-mediated diseases are a group of conditions that are caused by the overproduction of immunoglobulin E (IgE) antibodies. These antibodies are produced by the immune system in response to allergens such as pollen, dust mites, and certain foods. IgE-mediated…

Invented by John Dixon Gray, Heyue Zhou, Sorrento Therapeutics Inc Antibody therapeutics that bind CTLA4, also known as cytotoxic T-lymphocyte-associated protein 4, have been gaining attention in the pharmaceutical industry due to their potential in treating various diseases. CTLA4 is a protein that regulates the immune system by suppressing the activation of T-cells. By blocking…

Invented by Michaela Kniessel, Christine Halleux, Shou-Ih Hu, Beate Diefenbach-Streiber, Josef Prassler, MORPHYSYS AG, Mereo Biopharma 3 Ltd Polynucleotides that encode antibodies against sclerostin are becoming increasingly popular in the biopharmaceutical industry. Sclerostin is a protein that is primarily produced by osteocytes, which are cells that are responsible for bone formation and maintenance. Sclerostin inhibits…

Invented by Larry Green, Hiroaki Shizuya, Ablexis LLC The market for non-human mammals for the production of chimeric antibodies is a rapidly growing industry. Chimeric antibodies are a type of monoclonal antibody that is created by combining the variable regions of a human antibody with the constant regions of an animal antibody. This process allows…

Invented by Eric V. Shusta, Angela R Jones, Charles C. Stutz, Wisconsin Alumni Research Foundation The blood-brain barrier (BBB) is a highly selective membrane that separates the circulating blood from the brain’s extracellular fluid. It is a critical component of the central nervous system, as it protects the brain from harmful substances while allowing essential…

Invented by Aaron Keith CHAMBERLAIN, Bassil Dahiyat, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, Xencor Inc The market for Fc variants with modified binding to FcRn is rapidly growing due to their potential therapeutic benefits. FcRn is a receptor that plays a crucial role in the recycling and transport of immunoglobulin G (IgG)…